Kohei Uchimura Selected Research

camostat

8/2021	A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte injury in metabolic syndrome model rats.
12/2016	Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases.
10/2016	A serine protease inhibitor attenuates aldosterone-induced kidney injuries via the suppression of plasmin activity.
2/2016	Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model.
1/2015	The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects.
7/2013	The antifibrotic effect of a serine protease inhibitor in the kidney.

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Kohei Uchimura Research Topics

Disease

6	Fibrosis (Cirrhosis) 11/2021 - 10/2012
3	Hypertension (High Blood Pressure) 08/2021 - 10/2012
2	Inflammation (Inflammations) 05/2022 - 03/2015
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 05/2022 - 08/2021
2	Insulin Resistance 08/2021 - 03/2014
2	Wounds and Injuries (Trauma) 08/2021 - 10/2016
2	Proteinuria 08/2021 - 10/2012
2	Ureteral Obstruction 10/2016 - 07/2013
2	Chronic Renal Insufficiency 02/2016 - 01/2015
2	Obesity 03/2015 - 04/2014
1	Hyperthyroidism 03/2022
1	Hypothyroidism 03/2022
1	Ischemia 03/2022
1	Thyrotoxicosis 03/2022
1	Deficiency Diseases (Deficiency Disease) 03/2022
1	IGA Glomerulonephritis (IGA Nephropathy) 11/2021
1	Hypoxia (Hypoxemia) 11/2021
1	Nephrosclerosis 11/2021
1	Body Weight (Weight, Body) 08/2021
1	Rodent Diseases 08/2021
1	Premature Aging 01/2020
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2019
1	Solitary Kidney 01/2018
1	Obstructive Lung Diseases (Obstructive Lung Disease) 12/2016
1	Chronic Obstructive Pulmonary Disease (COPD) 12/2016
1	Pulmonary Emphysema 12/2016
1	Cystic Fibrosis (Mucoviscidosis) 12/2016
1	Kidney Diseases (Kidney Disease) 10/2016
1	Endotoxemia 03/2015
1	Fatty Liver 04/2014
1	Glucose Intolerance 04/2014
1	Chronic Kidney Failure (Chronic Renal Failure) 10/2012
1	Hypertrophy 10/2012

Drug/Important Bio-Agent (IBA)

8	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 08/2021 - 10/2012
6	camostatIBA 08/2021 - 07/2013
4	Serine Proteases (Serine Protease)IBA 08/2021 - 03/2014
3	Proteins (Proteins, Gene)FDA Link 11/2021 - 10/2012
3	SaltsIBA 01/2018 - 10/2012
3	AntioxidantsIBA 01/2018 - 01/2015
2	Thyroid Hormone Receptors (Thyroid Hormone Receptor)IBA 03/2022 - 11/2021
2	prostasinIBA 08/2021 - 03/2014
2	Toll-Like Receptor 4IBA 08/2021 - 03/2014
2	Glucose (Dextrose)FDA LinkGeneric 08/2021 - 03/2015
2	RNA (Ribonucleic Acid)IBA 01/2019 - 01/2018
2	Adenine FDA LinkGeneric 02/2016 - 01/2015
2	CollagenIBA 07/2013 - 10/2012
1	CytokinesIBA 05/2022
1	Thyroid HormonesIBA 03/2022
1	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2022
1	Thyroxine (Levothyroxine)FDA LinkGeneric 03/2022
1	LigandsIBA 03/2022
1	ArginaseIBA 03/2022
1	EnzymesIBA 03/2022
1	ParaffinIBA 11/2021
1	PotassiumIBA 01/2019
1	Small Nuclear RNA (snRNA)IBA 01/2019
1	Angiotensin IIIBA 01/2018
1	BenzbromaroneIBA 01/2018
1	ethyl N- allyl- N- (2- methyl- 3- (4- (4- amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonateIBA 12/2016
1	Peptide Hydrolases (Proteases)FDA Link 12/2016
1	Protease Inhibitors (Protease Inhibitor)IBA 12/2016
1	AldosteroneIBA 10/2016
1	Fibrinolysin FDA Link 10/2016
1	Telmisartan (Micardis)FDA Link 02/2016
1	Toll-Like Receptors (Toll-Like Receptor)IBA 03/2015
1	Messenger RNA (mRNA)IBA 01/2015
1	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2015
1	Triglycerides (Triacylglycerol)IBA 04/2014
1	Transforming Growth Factors (Transforming Growth Factor)IBA 07/2013
1	Plasminogen Activators (Plasminogen Activator)IBA 07/2013
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 07/2013
1	Hydroxyproline (4 Hydroxyproline)IBA 07/2013
1	Connective Tissue Growth FactorIBA 07/2013
1	nephrinIBA 10/2012
1	CreatinineIBA 10/2012

Therapy/Procedure

1	Renal Dialysis (Hemodialysis) 01/2020
1	Oral Administration 01/2018
1	Therapeutics 02/2016
1	Nephrectomy 10/2012